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Hodgkin's disease, lymphocyte depleted type
Epidemiology:
1) least common variant of Hodgkin's disease.
2) more common in older people and HIV+ individuals.
Pathology:
1) diffuse infiltrate, often hypocellular
2) large numbers of Reed-Sternberg cells & bizarre variants
Immunophenotype: tumor cells
- CD15 +/-
- CD30 +
- CD45 -
- B-cell & T-cell antigens - (required for diagnosis)
- EMA -
Genetics:
- Ig & TCR genes germline
Clinical manifestations:
1) frequently abdominal lymphadenopathy, spleen, liver & bone marrow involvement without peripheral adenopathy
2) usually advanced stage at diagnosis
3) response to treatment similar to other subtypes
Interactions
disease interactions
General
Hodgkin's disease (Hodgkin's lymphoma)
References
- Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML,
Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al.
A revised European-American classification of lymphoid
neoplasms: a proposal from the International Lymphoma Study
Group.
Blood. 1994 Sep 1;84(5):1361-92. Review.
PMID: 8068936